Protevo Bio IGF1-LR3 – Human Insuline-like Growth Factor 1

Protevo Bio IGF1-LR3 is a recombinant analogue of human insulin-like growth factor 1, engineered for significantly enhanced biological potency and stability in cell culture environments. By incorporating an N-terminal extension and a specific amino acid substitution, this long-acting variant exhibits reduced binding affinity for IGF-binding proteins (IGFBPs), which typically inhibit the activity of native IGF-1. This modification extends the half-life of the protein in media, allowing for sustained stimulation of cell proliferation and survival at lower concentrations.

Produced via E. coli fermentation and purified using scalable, animal-free methods, this growth factor serves as a high-performance alternative to recombinant insulin in chemically defined media. It is particularly effective for supporting the expansion of stem cells and muscle progenitors in cultivated meat applications. The protein is supplied as a lyophilised powder with high purity and low endotoxin levels, ensuring consistent reproducibility for both research and large-scale biomanufacturing workflows.