Smart MCs Silk Fibroin Methacryloyl (SilkMA)

Smart MCs Silk Fibroin Methacryloyl (SilkMA) is a specialised, animal-origin-free (ACF) hydrogel precursor designed to meet the rigorous demands of cultivated meat production. It solves the critical challenge of creating a biomimetic environment that supports robust cell proliferation and differentiation. This material forms a stable, biocompatible matrix via light-based cross-linking, offering researchers precise control over the cellular microenvironment in serum-free and chemically defined systems.

The key differentiator is its foundation in methacryloyl-modified silk fibroin, a high-molecular-weight polypeptide renowned for its exceptional biocompatibility and controlled biodegradability. The methacrylation process transforms the silk into a water-soluble precursor that can be rapidly photocured. This provides a highly tuneable "blank slate" where stiffness, porosity, and surface charge can be optimised to mimic native bovine, porcine, or avian muscle and connective tissues.

Validated across a range of mammalian cell types, SilkMA is highly compatible with the diverse cell lines required for cellular agriculture. Its performance in 3D bioprinting and modular tissue engineering ensures structural integrity during the maturation phase. The material is supplied with a certificate of analysis to support factual scientific workflows and regulatory documentation during R&D and pilot-scale studies.

Supplied as a kit including LAP photoinitiator in light-protective bottles. The standard polymer-to-LAP ratio is 1 g SilkMA per bottle with 0.05 g LAP. Due to its photo-reactive nature, the material must be stored in a dark place; it remains stable at room temperature for 3 months, at 4 °C for 12 months, or at -20 °C for up to 18 months. Long-term storage at -20 °C is recommended to ensure maximum product longevity.