Qkine Recombinant Bovine/Porcine NRG-1 Protein

Qkine's food grade bovine/porcine neuregulin-1 (NRG-1) is an ErbB receptor ligand that regulates muscle cell differentiation, maturation, and neuromuscular junction formation through ErbB2/ErbB3 heterodimer signalling. NRG-1 enhances myotube formation, promotes the development of mature muscle tissue characteristics including sarcomere organization and contractile protein expression, and supports the transition from proliferating myoblasts to terminally differentiated muscle fibres in cultivated meat production.

This food-grade recombinant protein is produced in mammalian cells expression systems and purified to >98% purity by SDS-PAGE quantitative densitometry. Manufactured in the UK under a HACCP food manufacturing regime, the protein is animal-origin-free (AOF), carrier protein-free, and tag-free to ensure exceptional purity and lot-to-lot consistency suitable for food applications. Comprehensive quality control includes mass spectrometry confirmation of expected molecular weight, recovery testing from stock vials (>95%), endotoxin analysis (<0.05 EU/μg protein), and full traceability documentation including certificates of analysis, certificates of origin, allergen analysis, beta-lactam-free certification, and animal-origin-free verification.

This protein is supplied lyophilized and should be reconstituted in 10 mM HCl or phosphate buffer at concentrations above 50 µg/mL, with optional addition of carrier protein for enhanced stability. Single-use aliquots are recommended to maintain protein integrity, with storage at -20°C for short-term use or -80°C for long-term storage. Suitable for cultivated meat media optimization, process development, commercial-scale production, and regulatory submissions. This food-grade protein is manufactured to support novel food dossier preparation, regulatory approval processes, and commercial manufacturing under GMP-equivalent standards.